Based on a true story, a poor Illinois town unites behind its football team and unlikely quarterback, Jasmine Plummer (Keke Palmer), the first female in Pop Warner's history. Under the tutelage of her uncle Curtis (Ice Cube), a former high school football star, Jasmine leads her team, the Minden Browns to the Pop Warner Super Bowl and inspires the town of Minden, Illinois, to reclaim its former glory.
Will Smith plays Robert Neville, a scientist unable to stop the spread of a terrible man-made virus that is incurable. Immune, he appears to be the last human survivor in New York City and perhaps the world. For three years, Neville has sent out daily radio messages, desperate to find other survivors. But he is not alone.
Mutant victims of the plague – “The Infected” -- lurk, watching Neville's every move... waiting for him to make a fatal mistake. Perhaps mankind's last, best hope, Neville is driven by only one remaining mission: to find a way to reverse the effects of the virus using his own immune blood. But he knows he is outnumbered ... and quickly running out of time.